Enlightening, Hopeful Account

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I have been interested in genome research since I first heard about it. As a genealogy researcher, I am curious about what we inherit from our ancestors. I seek out family resemblances and inherited traits, finding my eyes in one relative, my body type in another.

I wonder what health issues I inherited, or did not inherit. My mother had autoimmune diseases, and so do I. My grandfather had horrible ragweed allergies, and so does our son. My father had non-Hodgkin's lymphoma, and so does my cousin. My aunt and her two children struggled with alcoholism. Two grandfathers (aged 52 and 68) and an uncle (age 34) died of heart attacks.

For some people, their genes are secret time bombs. A healthy athlete suffers a sudden heart attack and dies. A baby's normal progress stops, and even regresses.

What if there was a test that could warn us of impending or likely health issues so doctors could be prepared to remedy or even cure them? What if it was affordable for everyone? What if if was part of our normal preventative health care insurance?

This could be reality.

The Genome Odyssey is a fascinating narrative of Dr. Ashley's research in genome sequencing and how it was applied to solve medical mysteries.

The science is very accessible in presentation, so that even non-medical folk like myself can understand how genes and sequencing works. The personal stories of those whose lives were changed through genome sequencing and genetic therapy are affecting. For some, simple OTC supplements changed their life.

The author addresses the current Sars-CoV-2 pandemic, telling how the scientific community swung into action even as governments floundered, and explaining how vaccines was developed and how the different kinds work on the virus.

"Could even more widespread use of genomics have gotten us further ahead of this pandemic to begin with?", he asks. He notes that wastewater can predict which community will have the next rise in infections. If we systematically tested wastewater the way we test drinking water, we could be prepared to prevent disease flareups.

In a capitalist, profit-driven health system, the question is who will pay. Will the rich only benefit, or those victims of rare diseases who are covered by research grants? Another issue to be addressed is the privacy of genome information and its use. Ashley adds, "Just because we can, doesn't mean we should. Nor does it mean that we can afford it."

Yet the possibilities of what doctors will be able to do in the future are endless.

I received an ARC from the publisher through Bookish First. My review is fair and unbiased.